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Generally the duration of treatment varies from a few days to two weeks with a maximum, including the tapering off process, of four weeks. Treatment should be as short as possible. The tablet should not be swallowed and the tablet should not be taken with water. Stilnox sublingual tablet should be placed under the tongue, where it will disintegrate. The effect of Stilnox may be slowed by ingestion with or immediately after a meal. Use With CNS DepressantsÄosage adjustment may be necessary when Stilnox is combined with other CNS-depressant drugs because of the potentially additive effects. The recommended dose of Stilnox in both of these patient populations is 5 mg once daily immediately before bedtime. Patients with hepatic insufficiency do not clear the drug as rapidly as normal subjects. Special PopulationsÄ®lderly or debilitated patients may be especially sensitive to the effects of zolpidem tartrate.
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The recommended initial doses for women and men are different because zolpidem clearance is lower in women. The total dose of Stilnox should not exceed 10 mg once daily immediately before bedtime.
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In some patients, the higher morning blood levels following use of the 10 mg dose increase the risk of next day impairment of driving and other activities that require full alertness. If the 5 mg dose is not effective, the dose can be increased to 10 mg. The recommended initial dose is 5 mg for women and either 5 or 10 mg for men, taken only once per night immediately before bedtime with at least 7-8 hours remaining before the planned time of awakening. Use the lowest effective dose for the patient.